Research Summary

Adding Hands-On Manual Therapy to Exercise May Ease Knee Arthritis Pain in the Short Term

Not medical advice. This is a plain-English summary for general information. Talk to your doctor or physical therapist before changing your care. Read our medical disclaimer.

Adding hands-on manual therapy to an exercise program appears to give people with knee osteoarthritis extra pain relief and better function for a while, but the extra benefit does not seem to last long term. That is the main finding of a new systematic review in the European Journal of Pain.

What was studied

Physiotherapy researchers in Brazil and Australia searched six medical databases for randomized clinical trials comparing two approaches for knee osteoarthritis: exercise alone, or exercise plus manual therapy (hands-on techniques such as joint mobilization done by a therapist). They pooled the results of 29 randomized trials in a meta-analysis and rated how trustworthy the evidence was using the GRADE system.

Key findings

  • Compared with exercise alone, manual therapy plus exercise reduced pain right after treatment, in the short term and in the medium term.
  • Physical function also improved more in the short and medium term.
  • No significant extra benefit was found in the long term for either pain or function.

What it means for people with knee pain

Exercise remains the foundation of knee arthritis care. This review suggests manual therapy can be a useful add-on, especially early in rehab, when pain can make exercise hard to start. The authors describe it as a way to support exercise, not replace it. If you see a physical therapist, it is reasonable to ask whether hands-on treatment could help you get your exercise program going.

Limitations

The authors rated the certainty of most results as very low, with only the medium-term pain result reaching moderate certainty. The trials differed in the techniques and programs used, and no long-term benefit was shown. The review did not find eligible studies on pressure pain sensitivity.

Source: da Silva VR, et al. Additional Effects of Manual Therapy to Exercise on Pain and Function in Individuals With Knee Osteoarthritis: A Systematic Review and Meta-Analysis. European Journal of Pain, October 2026. doi:10.1002/ejp.70397. PMID 42885413. Read the original

Frequently asked questions

What is manual therapy for knee arthritis?
Manual therapy means hands-on techniques done by a trained clinician, usually a physical therapist, such as moving or mobilizing the joint and surrounding tissues. In this review it was tested as an add-on to exercise.
Does manual therapy replace exercise for knee osteoarthritis?
No. The review compared exercise plus manual therapy with exercise alone. Its authors describe manual therapy as a way to support exercise, particularly at the start of rehab, not a substitute for it.
How long do the benefits of manual therapy last?
The review found extra benefits for pain and function in the immediate, short and medium term, but no significant extra benefit in the long term.

Sudden severe pain, swelling, or can't bear weight? Seek medical care promptly. In an emergency call 911.